Tacrolimus monohydrate 109581-93-3 Antibiotic
Totogi:T/T, L/C
Puna'oa:Saina
Taulaga Va'a:Beijing/Shanghai/Hangzhou
Gaosi gaosiga:1kg/masina
Poloaiga(MOQ):1g
Taimi muamua:3 Aso Galue
Tulaga teuina:Teu i totonu o se nofoaga malulu, matutu, potu vevela.
Mea fa'apipi'i:fagu, fagu
Tele le afifi:1g/ fagu, 5/ fagu, 10g/ fagu, 50g/fagu, 500g/fagu
Fa'amatalaga saogalemu:UN 2811 6.1/PG 3
Folasaga
Tacrolimus, o se vailaʻau faʻamaʻi puipuia.A mae'a le fa'asoloina o totoga allogeneic, e feololo le lamatiaga o le te'ena o totoga.Ina ia faʻaitiitia le lamatiaga o le teena o okeni, ua tuʻuina atu le tacrolimus.E mafai fo'i ona fa'atau atu le vaila'au e fai ma vaila'au fa'apitoa mo le togafitia o fa'ama'i T-cell-mediated e pei ole eczema ma le psoriasis.E mafai ona fa'aoga e togafitia ai ma'i mata mago i pusi ma maile.
Tacrolimus taofia calcineurin, lea e aʻafia i le gaosiga o le interleukin-2, o se mole e faʻaleleia ai le atinaʻeina ma le faʻateleina o sela T, e avea o se vaega o le aʻoaʻoina o le tino (poʻo le fetuutuunai) tali atu.
Fa'amatalaga (USP43)
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e pe toetoe a pa'epa'e tioata tioata |
| Fa'ailoaga | IR, HPLC |
| Solubility | E matua solu i le methanol, e mafai ona solu i le N,N dimethylformamide ma le ava malosi, toetoe lava i le solu i le vai. |
| Toega ile mu | ≤0.10 % |
| O mea eleelea fa'aletino (faiga-2) | Ascomycin 19-epimer ≤0.10 % |
| Ascomycin ≤0.50 % | |
| Desmethyl tacrolimus ≤0.10 % | |
| Tacrolimus 8-epimer ≤0.15 % | |
| Tacrolimus 8-propyl analog ≤0.15 % | |
| Le iloa le mama -I ≤0.10 % | |
| Le iloa le mama -II ≤0.10 % | |
| Le iloa le mama -III ≤0.10 % | |
| Aofa'i le mama ≤1.00 % | |
| Va'aiga mata'utia (fa'atatau) (10mg/ml ile N,Ndimethylformamide) | -110.0° ~ -115.0° |
| Suavai (e KF) | ≤4.0% |
| Soli totoe (e le GC) | Acetone ≤1000ppm (I totonu o le fale) |
| Di-isopropyl ether ≤100ppm (I totonu-fale) | |
| Ethyl eter ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Su'ega microbial (i totonu o le fale) | Ole aofa'i ole microbial aerobic ≤100cfu/gm |
| Aofa'i fa'afefete ma fa'ailoga ≤10cfu/gm | |
| O meaola fa'apitoa (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) e tatau ona toesea. | |
| Su'esu'ega (e le HPLC) (i luga o le fa'aogaina e leai se vai ma so'o se fa'avae) | 98%~102% |
